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Indeed, it was recently demonstrated that the pentose phosphate pathway (PPP), a major contributor of NADPH for the maintenance of glutathione in its reduced state, is critical for NRF2-induced proliferation [58, 59]

60 The Role of GSH in Antibiotic Resistance Mechanisms Antioxidant Defense of GSH on Antibiotic Susceptibility Bactericidal antibiotics typically kill bacteria by generating reactive oxygen species (ROS) within their cells