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Mechanistically, curcumin enhances the expression of antioxidant enzymessuch as HO-1 and Superoxide dismutase (SOD)via activation of the GSK3Nrf2 axis, while simultaneously inhibiting M1 macrophage polarization and reducing the secretion of pro-inflammatory cytokines such as TNF- and IL-6 (Li X et al., 2020)

Darker skin can develop underneath both eyes, which may be shades of brown, blue, black or purple

10.1016/j.biopsych.2008.05.006 37 CucinottaF.RicciardelloA.TurrizianiL.ManciniA.KellerR.SaccoR.et al (2022)

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Furthermore, asparagine can contribute to leukemic tumor cells metastasis (mouse model) through the enhancement of c-Myc expression [219]