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doi: 10.3389/fmed.2025.1604319

Antioxidant support is a long-term strategy for cellular health rather than an instant fix

Agents 38 , 99107 (2011)

initially showed that icv injection of somatostatin-28 or ODT8-SST abolished the plasma epinephrine elevation elicited by a variety of stressors including acute exposure to tail suspension, intermittent loud noise, ether stress, or metabolic hypoglycemic stress induced by the injection of 2-deoxyglucose or insulin in rats (Fisher and Brown, The centrally mediated action of the SST-agonists was demonstrated by the lack of effect when ODT8-SST was administered peripherally at a dose 100-times higher than icv (Fisher and Brown, 1984)