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The glycocalyx as a permeability barrier: basic science and clinical evidence

The rate of weight loss mattersmore gradual reduction may cause fewer menstrual disruptions than rapid weight loss, though tirzepatide-induced weight loss occurs relatively quickly compared to lifestyle modification alone

The main caveat: community doses cluster well below the 12 mg trial peak, so trial percentages are not directly applicable

The indirect costs of IC/BPS, including time away from work and lost productivity while working, are particularly significant since the condition primarily affects working age adults, and especially women aged 25-50 years

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