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The GG genotype lowers homocysteine but raises risk for: Systemic lupus erythematosus Bipolar disorder Schizophrenia Congenital facial and spinal malformations Down syndrome Methionine Synthase Reductase: An AG substitution at base pair 66 affects ~ 30% of individuals

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In addition, research indicates that MGF variants have potential applications in nerve regeneration, making them a topic of interest in neurological research and neurodegenerative disease treatments