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Generally, ensuring solubilization and preventing misfolding is a primary event of HSP70 activity, whereas the ubiquitinproteasome system (UPS) is a compensatory mechanism to degrade proteins that are irreversibly damaged or become damaged at excessive levels unable to be refolded

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[DOI] [PMC free article] [PubMed] [Google Scholar] 173.Jrvi N., Parviainen T., Maljanen N.-L., Kobayashi Y., Kujanp L., Ercili-Cura D., Landowski C.P., Ryynnen T., Nordlund E., Tuomisto H.L