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No dependency, withdrawal syndrome, or suppression of natural sleep architecture has been reported in DSIP studies, contrasting favorably with benzodiazepine-class sleep agents

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Topical peptides are useful for certain applications (GHK-Cu copper peptide has reasonable evidence for topical activity), but for the major therapeutic peptides growth hormone secretagogues, BPC-157, Epithalon systemic delivery is required to produce the effects seen in the research literature