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The use of the chamber has been documented in a variety of species including humans [34], rodents [35], horses [36], swine, and poultry [37]
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[DOI] [PubMed] [Google Scholar] 18.Carmen GY, Victor SM
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Immune effects are restorative, not overstimulating: It rebalances T-cell ratios, upregulates IL-2 in aged tissues, and improves neuroimmune integration, suggesting a targeted recalibration of immune tone rather than indiscriminate boosting. It restores circadian and hormonal rhythms: By stimulating melatonin synthesis, protecting pineal structure, and re-entraining clock genes, Epitalon may counter the widespread circadian drift of aging, with implications far beyond sleep, touching immunity, metabolism, and neuroprotection
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