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The molecular docking and dynamics simulation studies indicated that letrozole has a significant binding affinity of -9

ScienceDirect , PLoS ONE , vol

The evidence was based on experimental data only briefly described in the patent and included models of: gastric ulcers, heart damage, liver damage, pancreatic injury, kidney damage, experimental diabetes, fever, edema, rhinitis, bone fracture, burns, skin wounds, hypersensitivity reactions, pupil dilation, colon injury, tumour growth, radiation injury, red blood cell development, fertility and lactation, tooth damage, several types of central and peripheral nerve damage, and survival from infection with Trichinosis (i.e., tapeworms) as well as several viruses

Immediate IgE-mediated reactions have been reported but are much less common than delayed cutaneous reactions

Elevated blood pressure, cardiometabolic risk and target organ damage in youth with overweight and obesity