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HTRA1 are serine proteases composed of four protein domains for the binding of the insulin-like growth factor binding domain (ILGF), kazal domain, trypsin-like peptidase domain, and PDZ domain to accomplish cellular functions

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For example, one research group studied the effect of LA in collagen-induced arthritis (CIA) mice and its activity as a zonulin antagonist (48)

"Theoretically, collagen could accumulate a certain type of pesticide commonly applied to grains that are fed to livestock," says Schoenfeld