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Disclosure of interest: All authors: nothing to disclose E-Posters - RECOVERY, REHABILITATION AND OUTCOME 03.00 - RECOVERY, REHABILITATION AND OUTCOME - 03.01 - REHABILITATION P2213 - ESOC25-667 BARRIERS TO ACCESSING AND PROVIDING EXERCISE REHABILITATION FROM THE PERSPECTIVE OF STROKE SURVIVORS AND LEISURE CENTRE INSTRUCTORS Lucy Watson 1 , Esmee Thrasher 1 , Hannah Jarvis 1 1 Lancaster University, Lancaster, United Kingdom Background and Aims: Exercise rehabilitation after a stroke is vital to improve physical and psychological well-being, but stroke survivors experience an array of barriers preventing participation

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When alterations in nutritional status or mitochondrial dysfunction induce changes in the NAD + /NADH and AMP/ATP ratios, the expression of the PGC-1 coactivator family of proteins increases, and these proteins interact with nuclear respiratory factor (NRF)1 and 2, thereby activating the phosphorylation of AMPK and upregulating mitochondrial gene expression, transcription and replication [38, 39]