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For effectively targeting the brain using bioactive substances, various novel strategies that include invasive systems, non-invasive/miscellaneous systems and various alternative routes for drug delivery into CNS have been designed and are shown in Fig

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In recent years, significant advancements in the development of an applied Monitoring and Evaluation (M&E) Framework to assess impact within the context of Digital Twins, have been achieved, and through ongoing applied projects, this is moving at pace to deliver success