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Passive diffusion also occurs throughout the intestinal tract, allowing approximately 1% of oral doses to be absorbed without intrinsic factor

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Regulatory watch Last reviewed Jul 12, 2026 Next review Jul 24, 2026 Evidence snapshot Human trial record: a Phase 1 safety and pharmacokinetics registry entry has no posted efficacy result

Previous colectomy with an end-ileostomy or with a continent ileal pouch does not preclude pregnancy, and for some women, vaginal delivery is still an option