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Studies demonstrate protection against brain edema, reduced inflammatory cytokines TNF- and IL-1, and enhanced neuronal survival following injury

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Nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) increases ROS production, and stimulation of FLSs with NOX4 elevates the expression of vascular cell adhesion molecule 1 (VCAM1) and VEGF, contributing to vascular neogenesis and proliferation and migration of FLSs (193)

[DOI] [PMC free article] [PubMed] [Google Scholar] 2.Williamson G., Manach C