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The study further showed that restoring mitochondrial biogenesis through PGC-1 overexpression enhances T cell metabolic fitness and anti-tumor function, highlighting the critical role of metabolic regulation in determining T cell efficacy in the TME ( Moreover, hypoxic tumor cells reprogram their antioxidant systems to cope with elevated ROS levels

This allows identification of individual effects and any adverse reactions

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Next, a Selleck Chemicals library of FDA-approved drugs was screened for radioprotection