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Since CD45RO has less phosphatase activity than CD45RA 44 , the transition of CD45RA to CD45RO suggests that immune cells have become more sensitive to external stimuli 45

While new studies may dispute this, it's important to keep in mind many of these are observational studies that look at exposure in the home and do not account for confounding variables, like being exposed to tobacco smoke or E-Cigarette aerosol outside the home (4)

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