Future studies should investigate whether p53 ablation in adipocytes, with concomitant reduction in the abundance of AT macrophages, might lead to differences in weight (re-)gain after return to normal or obesogenic diet, to further test the hypothesis that adipocyte p53 is key in establishing an immuno-obesogenic memory of AT that promotes weight regain
Kopolrat K, Sithithaworn P, Kiatsopit N, Pitaksakulrat O, Tesana S, Andrews RH, Petney TN
While the therapeutic effect is quick, frequent dosing is needed and there is potential for a quick relapse and rebound of psoriasis (Table 1)
Morin offsets PTZ-induced neuronal degeneration and cognitive decrements in rats: the modulation of TNF-/TNFR-1/RIPK1,3/MLKL/PGAM5/Drp-1, IL-6/JAK2/STAT3/GFAP and Keap-1/Nrf-2/HO-1 trajectories
A., Lin L., et al., MitoNEET (CISD1) Knockout Mice Show Signs of Striatal Mitochondrial Dysfunction and a Parkinson's Disease Phenotype, Acs Chemical Neuroscience 8, no