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This is the common, diagnosed cause of B12 deficiency in the UK
Post-Surgery Patients People whove had gastric bypass or small intestine surgery may require B12 shots because their bodies can no longer absorb the vitamin effectively through food or oral supplements
How Often Should You Get B12 Shots
Options include: Changing from one oral tablet formulation to another with different excipients Discussing sublingual preparations as an alternative (though evidence doesn't suggest superior absorption to oral tablets) For those on injections, checking the specific product's SmPC for excipient information In the UK, hydroxocobalamin injection is the licensed first-line treatment for B12 deficiency requiring parenteral therapy
A 2015 Cell Metabolism study that first characterized MOTS-c as a mitochondria-derived regulator of metabolic homeostasis capable of reducing obesity and insulin resistance in animal models was foundational in establishing this peptide class
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