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A deficiency of TNSALP in HPP leads to decreased overall ALP activity and subnormal ALP levels

Zhou, N, Vlahos, I, Hooda, Z, Hofstetter, WL, Mehran, RJ, Rajaram, R, Rice, DC, Sepesi, B, Swisher, SG , Vaporciyan, AA, Walsh, GL, Mitchell, KG, Antonoff, MB

Similarly, mice exposed to CUMS for 6 weeks showed an increased interferon-gamma (IFN-) and decreased anti-inflammatory IL-10 levels, demonstrating anti-inflammatory suppression with further pro-inflammatory activation (Jia et al., 2024)

Abbas S, Karangwa E, Bashari M, et al

The authors concluded that NAC resulted in improved performance suggestive of oxidative stress having a causal role in the fatigue process