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In vivo experiments using electrocoagulation and cultured neural stem cells from the hippocampus of newborn rats confirmed that catalpol activates the stromal cell-derived factor-1 (SDF-1)/C-X-C chemokine receptor 4 (CXCR4) and PI3K/AKT/ERK signaling pathways, promoting the migration of neural stem cells by microvascular endothelial cells after anoxia

Importantly however, animal studies collectively emphasize two key principles: first, an adaptive T- and B-cell response can be elicited by myelin that degenerates in a specific way, without any deliberate upregulation of the systemic immune system

Neuropsychiatric profiles in mild cognitive impairment with Lewy bodies

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doi: 10.1046/j.1365-313x.2002.01391.x