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doi: 10.1159/000487639

Importantly, the proteomic similarity of Day 30 iHLOs to PHHs, with a 33.46% expression difference from liver tissue, underscores their physiological relevance compared to traditional models like HepG2 cells, which exhibit a 54.36% protein difference from liver tissue, or HepaRG cells, with a 45.40% protein difference

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Beyond its local gastrointestinal benefits, research suggests that orally administered BPC-157 can achieve systemic distribution, supporting healing processes throughout the body including joints, muscles, and connective tissues through mechanisms involving growth factor modulation and angiogenesis promotion

5.4 Advanced strategies for enhanced transepithelial transport using CPPs For physical mixing methods, the extent of intermolecular interaction between CPP and cargo is a key determinant for efficient delivery, as shown for penetratin and its analogs (Zhu et al., 2014)