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Markers of nitrosative stress are prevalent in tissues from both Parkinson's and Alzheimer's disease patients, indicating a significant role for nitric oxide in disease pathogenesis [59, 60]

Higher melanin levels result in darker skin tones

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But the same property that makes it useful in culture is what makes any extrapolation to human physiology fraught: broad, persistent activation of a receptor that regulates growth, metabolism, and cell survival across virtually every tissue is a fundamentally different proposition from a self-limiting local pulse

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