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This includes: Direct evidence: directly measured experimental support that blocking or preventing a KE prevents or impacts downstream KEs in the pathway in the expected fashion

In view of the GO results, the Kyoto Encyclopedia of Genes and Genomes (KEGG) network enrichment analysis highlighted a greater effect on a metabolic pathway, glutathione metabolism (path:ko00480), which included upregulated Ggt1 and downregulated Anpep, in OVX rats (Figure 2F, and see Supplementary Tables S7)

Chiuppesi, F

[PMID:20106400] Lin KH, Huang YJ, Hsu HH, et al

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