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Rhodiola rosea , Withania somnifera , and Eleutherococcus senticosus extracts downregulate the expression of ALOX5AP, DPEP2, and LTC4S genes involved in the biosynthesis of leukotrienes A, B, C, D, and E, resulting in inhibition of the leukotriene signaling pathway and suggesting their potential benefits in Alzheimer disease (Figure 9) [68]