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Abstract Background Desensitization of G proteincoupled receptors (GPCRs) refers to a rapid attenuation of responsiveness that occurs with repeated or continuous exposure to agonists

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Research (PMID: 11472075) shows this modification substantially reduces binding affinity to IGF-binding proteins (IGFBPs) compared to native IGF-1, resulting in a longer circulating half-life and sustained bioavailability in research models a key reason LR3 variants are used in preference to native IGF-1 in extended-duration studies