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Media Attributions FigB 5.1 by Carl Ruby, created with BioRender.com Fig 5.2 by Carl Ruby and OERU is licensed under CC BY FigB 5.3 by Carl Ruby, created with BioRender.com a chemical reaction in which a drug molecule loses electrons, often by gaining an oxygen atom or losing a hydrogen atom mediated by CYP a chemical reaction that involves the breaking of a bond in a molecule using water a chemical reaction where a drug molecule gains electrons, often by losing oxygen or gaining hydrogen formed when a drug is metabolized by phase I and phase II enzymes to produce inactive, less active, or toxic species of the original drug the name given to compounds that are foreign to the body, including drugs, environmental chemicals, and dietary substances nicotinamide adenine dinucleotide phosphate, in the reduced form is a coenzyme that is an electron donor, including drug metabolism mediated by cytochrome P450 an iron-containing compound found in hemoglobin that is critical for the enzymatic function of cytochrome P450 enzymes the process where oral drugs are partially metabolized by intestinal and liver enzymes before reaching systemic circulation, reducing drug bioavailability the clinical practice of measuring drug concentrations in the blood at intervals to ensure that a drug remains within a target therapeutic range while minimizing toxicity inactive compounds designed to be metabolized into active forms, which improves drug properties like solubility and absorption

Sagittaria sagittifolia polysaccharide protects against isoniazid- and rifampicin-induced hepatic injury via activation of nuclear factor E2-related factor 2 signaling in mice

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The intestinal microbiota regulates body composition through NFIL3 and the circadian clock