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Four key pathways have been implicated in the effects of hyperglycemia-induced tissue damage: the polyol pathway, AGE pathway, hexosamine biosynthetic pathway, and protein kinase C pathway

Avoid Touching : Remind patients not to touch the treated area immediately after the procedure, as this can lead to bruising and even introduce bacteria, increasing the risk of infection

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doi: 10.1097/01.all.0000173788.73401.69 39 RahmanI.KodeA.BiswasS

Sympatholysis enhances the release of local endogenous, short-lived vasodilators such as adenosine, ATP, prostaglandins, prostacyclin, bradykinin, and protons to act as a compensatory mechanism (58)