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This effect is further exacerbated by the APOE-4 and sTREM2 pathways (Biel et al., 2025), which likely underlie the higher prevalence and rapid progression of AD in woman (Vila-Castelar et al., 2025)

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This mechanism has been validated in RCTs in populations including older adults, hemodialysis patients, and schizophrenia patients on maintenance medication

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