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It is also investigated as a tool for probing the relationship between sleep architecture, circadian neuroendocrine output, and stress-response signaling

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This finding is particularly significant given that some trials extended to 24 weeks of continuous exposure and included individuals with obesity-related health conditions who might have higher baseline health risks

It is not approved for therapeutic use and is intended strictly for laboratory and investigative research purposes

As a result the response function of a metabolite or a reaction velocity to changes in a parameter or input may be nonlinear and non-monotone