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Some studies suggest that vitamin B12 may influence bacterial activity on the skin, which can play a role in the development of acne

Those following a vegan or strict plant-based diet are more likely to suffer from vitamin B12 deficiency

The advanced protocol should only be implemented after successful tolerance of lower doses and under appropriate medical supervision

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In patients with T2DM who do not have atherosclerotic cardiovascular disease (ASCVD)/indicators of high-risk, HF, or CKD and who need to minimize hypoglycemia and/or promote weight loss, GLP-1 RAs are generally recommended as a second or third-line option as add-on to metformin therapy