Role of glutathione metabolism in the glutamate-induced programmed cell death of neuronal-like PC12 cells
A recent study suggested that plasma levels of 5-MT, a compound related to serotonin metabolism, may be decreased in CFS patients, but this has been interpreted as a confounder caused by serotonin-selective reuptake inhibitor (SSRI) use in these patients ( The principal role of carnitine is to transport long-chain fatty acids into the mitochondria for energy production via beta-oxidation ( While carnitine supplementation could have benefits, some recent studies suggest that chronic oral L-carnitine administration may be associated with an increased risk for atherosclerosis via increased trimethylamine (TMA) and/or trimethylamine N-Oxide (TMAO) levels ( Mitochondrial dysfunction has been suggested to contribute to CFS ( The mechanisms that link carnitine intake, S-5-HT, and fatigue, in both CFS and hypothyroidism, are yet unknown
Liu, Y., et al., Alpha-lipoic acid improves high-fat diet-induced hepatic steatosis by modulating the transcription factors SREBP-1, FoxO1 and Nrf2 via the SIRT1/LKB1/AMPK pathway
doi: 10.1016/j.neulet.2016.03.023 316 ProfitaMBonannoASienaLFerraroMMontalbanoAMPompeoFet al
The inclusion-delivery interval tended to be longer in the NAC-treated severe IPTB cases, compared with severe cases who received placebo ((58 [16
