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GLP-1 + GIPs ability to activate both GLP-1 and GIP receptors enhances insulin secretion and improves glucose regulation

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Anpep, also known as aminopeptidase N or CD13, constitutes a multifunctional membrane-bound zinc-dependent metalloprotease that is ubiquitously conserved in renal, intestinal, placental, brain, and hepatic tissues and is also expressed on monocytes and myeloid progenitor cells (Rawlings et al., 2006)