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Recommendations to Blueprint Conduct product-specific clinical trials with objective endpoints and disclose active concentrations to enhance transparency

[ 297 ] The protein APOBEC3A (A3A), originating from an essential enzyme in the innate immune system, causes mutations in breast cancers by altering cytidines in singlestranded DNA to uridine

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Significantly, BBR has emerged as a widespread inhibitor of HDACs and is capable of down-regulating HDAC4, thereby enhancing epigenetic modifications through increased histone acetylation (Kandasamy et al., 2023)

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