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These imbalances of ROS with respect to antioxidants cause oxidative damage when ROS manage to react with the oxidizable substrate (proteins, lipids, carbohydrates and even the DNA molecules themselves)

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It is thought that something triggers the immune system to make antibodies against intrinsic factor

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In general, use caution when selecting a dosage for an elderly patient, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function and of concomitant disease or other drug therapy