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Despite substantial advances in our understanding of these mechanisms, effective therapeutic options remain extremely limited

Also, the mapping approach for transcriptomic data is based on the inclusion of highly transcribed genes and therefore is biased towards more abundant proteins, hence potentially missing lowly abundant proteins relevant for viral replication

Genome sequencing projects were particularly useful for the identification of large numbers of GSTs of unknown function in bacterial and yeast genomes (Vuilleumier and Pagni, 2002