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It was ssubsequently found that MC2R depended, for its trafficking to cell surface, on a small single trans-membrane domain protein the malfunction of which caused a clinical syndrome indistinguishable from that caused by the absence or malfunction of the MC2R

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Both the type of sugar and glycosidic bond (- or - and C - or O -glycoside) also affect flavonoids stability inside the colon (Reference Hein, Rose and vant Slot37) , with C-flavonoid glycosides showing slower metabolic rates than O -glycosides

Selective inhibition in astrocytes alone was sufficient to prevent non-cell-autonomous neuronal loss and prolong survival, as a mechanism of neurodegeneration driven by reactive astrocytes (Smith et al., 2020)

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