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The synthetic version used in research maintains the same amino acid sequence and biological activity as the naturally occurring fragment

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This pharmacological distinction is important for researchers designing experiments that depend on sustained versus transient receptor activation

To optimize drug design and develop therapies targeted at disease mechanisms involving the BBB or to improve drug delivery to the CNS, BBB models are required that adequately reflect in vivo conditions

That said, it is not a substitute for foundational health practices or for addressing underlying hormonal and metabolic issues