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Concluding remarks The levels and compartmentalization of NAD + dictate energy state that impinges on normal physiological and biological responses, as indicated by the regulatory role of NAD + in proper redox homeostasis, genomic stability, gene expression, circadian clock, inflammation, metabolism, cellular bioenergetics, mitochondrial homeostasis and adaptive stress responses

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The c-Met level was higher in pancreatic cancer tissue with PNI than in pancreatic cancer tissues without PNI (Fig