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Nicotine stimulates the expression of cFos protein in the parvocellular paraventricular nucleus and brainstem catecholaminergic regions

[31] 2004: A New York jury issued $20 million to the wife of a long-term smoker who died of lung cancer at the age of 57

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They can be used for up to 30 minutes before gradually tapering off, so the nicotine is sustained over a longer time, unlike the feast or famine delivery method of cigarettes, which can lead to crashes and a return to strong cravings after a short time

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