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Specifically, bloodletting puncture can suppress the expression of MAPK, ERK, p38, and their downstream molecules, MMP9 and AQP4, leading to enhanced neurological function, reduced brain edema, stabilization of the bloodbrain barrier, and decreased apoptosis

[11] This indicates that animal reproduction studies have shown an adverse effect on the fetus, and there are no adequate, well-controlled studies in pregnant women

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The systematic review protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO), registration number: CRD42024554513 (Available from) (NIHR, 2025)