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Common causes include pernicious anaemia (autoimmune condition), plant-based diets without supplementation, gastrointestinal surgery, and long-term use of metformin or proton pump inhibitors

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The biological activity attributed to BPC-157 in preclinical literature derives from the peptide sequence itself not the counterion

A 2021 clinical study of chronic knee pain patients found 87.5% reported significant relief after BPC-157, lasting 6 months to a year

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