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One study reported that vitamin B12 deficiency was associated with twice the risk of severe depression (4)

[4] [16] [26] While bromantane can inhibit the reuptake of serotonin, dopamine, and to a lesser extent norepinephrine in vitro in rat brain tissue, the concentrations required to do so are extremely high (50500 M) and likely not clinically relevant

PubMed Rosenstock J, et al