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Other clear exclusions include acromegaly or any GH-excess condition, active carpal tunnel syndrome (which GH signaling can worsen), pregnancy and breastfeeding, and pediatric patients, whose still-developing axis belongs in endocrinology

Merviel P, Cabry R, Lourdel E, Lanta S, Amant C, Copin H, Benkhalifa M

Obstet Gynecol Int 2013:859619

These cytokines transmit messages via intracellular proteins like Janus kinases (JAK), which enhance lymphocyte activation and proliferation [48, 49]

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