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Attempts to demetallate CuCP with copper-binding ligands In CuCP samples the copper eluted from the Sephadex G25 column in HMW region confirming that metal is strongly bound to the protein

Clinical trial data in the literature examining the biological effects of glutathione intake is fragmented with no clear guidelines for the clinician especially in the management of skin pigmentation issues

This review synthesizes insights into metal transporters to advance our understanding of their roles in maintaining systemic and brain Mn homeostasis under healthy conditions and their contribution to Mn dysregulation in disease states, particularly neurological disorders

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During maturation, the NOTCH precursor undergoes a complex process of modifications and cleavages, like the S1 cleavage catalyzed by a furin-like protease before translocation of the mature protein to the cell membrane (Kopan and Ilagan, 2009)