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MMP-2 mediates the degradation of collagen type IV and other components of ECM consequently, interfering with differentiation and proliferation (Moiseeva, 2001

The siRNAs were dissolved in an in vivo transfection reagent (TransIT In Vivo Gene Delivery System, Mirus) under sterile conditions

Strengths of this study were as follows: (1) it set out to investigate how riboflavin status affects the associations between polymorphisms affecting riboflavin-dependent enzymes and tHcy, rather than focussing on the effect of the substrates for the enzymes alone

[DOI] [PMC free article] [PubMed] [Google Scholar] 241

Brightens dark spots / uneven skin tone over time