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Persistent and uncontrolled oxidative stress and exacerbating NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasome activation during severe COVID-19 disease (Lage et al., 2022), induce production of pro-inflammatory cytokines, such as IL-1 and IL-18, that can be explained because of sharply decreased macrophage GSH intracellular levels associated with increased GSH efflux (Zhang T

L-theanine alleviates myocardial ischemia/reperfusion injury by suppressing oxidxative stress and apoptosis through activation of the JAK2/STAT3 pathway in mice

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Further, (AT 1 a/)mice reduced flight behavior in the elevated T-maze test (a model of anxiety and panic) and diminished fear responses despite threat levels (30)

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