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Notwithstanding their overall structural similarity to AMPA receptors, KARs exhibit a desensitized conformation that is distinct from that of most other iGluRs

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Functional testing may be required

PMCID: PMC9927842 Onyeakazi UM, Columb MO, Rosalind A, Kanakarajan S, Galley HF (2024) Melatonin treatment has consistent but transient beneficial effects on sleep measures and pain in patients with severe chronic pain: the DREAM-CP randomised controlled trial

A phosphorylation-dependent switch in the disordered p53 transactivation domain regulates DNA binding