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There is a theoretical concern, supported by some biological evidence, that elevated IGF-1 activity in a patient with occult or a history of certain hormone-sensitive cancers could be problematic

If particles remain after 30 minutes, treat the vial as degraded

434,435,436 Glycogen synthesized from glycolysis-derived G6P also repolarizes macrophages to an inflammatory phenotype via the pentose phosphate pathway and UDPG-P2Y14 signaling pathway

doi: 10.1186/s13148-022-01398-1 Summary Keywords post-acute infection syndromes, long Covid, ME/CFS, inflammation, stress, dysautonomia, hypothalamus-pituitary-adrenal axis (HPA axis), microbiota-gut-brain axis Citation Trautmann A (2025) Core features and inherent diversity of post-acute infection syndromes

PMID: 32 RudnickaESuchtaKGrymowiczMCalik-KsepkaASmolarczykKDuszewskaAMet al