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When there is a suspicion of symptomatic B12 deficiency it is important to measure the B12 serum determination (in addition to excluding other diseases, such as thyroid diseases and Lyme), even if anaemia has not been diagnosed

Formation of a stabilized cysteine sulfinic acid is critical for the mitochondrial function of the parkinsonism protein DJ-1

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The interplay of NAD + /NADP + metabolism with circadian clock is further evidenced by the oscillating redox, in which ROS levels display a different liver pattern compared to other tissues due to the unique NAD + oscillation in response to the autonomous hepatic clock