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In Russia, Semax has been: Approved as a pharmaceutical since 2011 Prescribed for ischemic stroke (acute and recovery phases) Used for cognitive disorders, including memory impairment and attention deficits Administered as a nasal spray, making it convenient and non-invasive Studied extensively, with hundreds of published scientific papers Given to healthy individuals for cognitive optimization (a practice common among Russian military and high-performance professionals) This decades-long track record of clinical use with a robust safety profile documented in Russian medical literature is one of the strongest arguments for Semax's inclusion on the US 503A compounding list

One group received local injection directly into the bone defect